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Aerosol-Based Detectors in Liquid Chromatography: Approaches Toward Universal Detection and to Global Analysis

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posted on 2023-05-24, 05:12 authored by Hutchinson, JP, Gregory Dicinoski, Paul HaddadPaul Haddad
© 2017 John Wiley & Sons, Inc. All rights reserved. This chapter discusses the various types of universal detection techniques that can be used in Liquid Chromatography (LC). It also discusses the advantages and disadvantages of aerosol detectors with particular reference to the factors that affect analyte response in these detectors and efforts that have been made to characterize these effects. Due to their inherent mode of operation, aerosol detectors are compatible with a wide range of volatile solvents consistent with the principles of green chemistry and allow these detectors to be hyphenated to a wide range of liquid chromatographic methods, including high temperature water and supercritical carbon dioxide chromatographic separations. Aerosol detectors are discussed in the context of global analysis and their use in combination with multidimensional separations. It discusses one of the approaches to overcoming the gradient effect to develop empirical models that relate detector response to both the composition of the mobile phase and the amount of analyte injected.

Funding

Australian Research Council

Pfizer

History

Publication title

Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques

Editors

PH Gamache

Pagination

191-220

ISBN

9780470937785

Department/School

School of Natural Sciences

Publisher

John Wiley & Sons, Inc.

Place of publication

New Jersey, USA

Extent

15

Rights statement

Copyright 2017 John Wiley & Sons, Inc.

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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