Cephalosporins

Dose adjustment in obesity is particularly important for cephalosporins since these agents are widely used for surgical prophylaxis and treatment of infections. Compared with other antibiotics such as vancomycin and aminoglycosides, there is a paucity of data on the pharmacokinetics of cephalosporins in obesity and dosing recommendations are scarce. The purpose of this chapter is to review and summarise the published data to assist in developing dosing recommendations for the use of cephalosporins in obesity.