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Experimental Models Used to Study Human Tuberculosis

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posted on 2023-05-22, 15:26 authored by O'Toole, RF
Mycobacterium tuberculosis causes more deaths in humans than any other bacterial pathogen. The most recent data from the World Health Organization reveal that over 9 million new cases of tuberculosis occur each year and that the incidence appears to be increasing with population growth. Despite the global burden of tuberculosis, we are still reliant on relatively dated measures to prevent, diagnose, and treat the disease. New, more effective tools are needed to diminish the incidence of tuberculosis. M. tuberculosis lacks a natural host beyond humans and, hence, surrogate models have been employed in the study of the pathogen. The discovery and development of new vaccines, diagnostics, or antitubercular drugs are dependent upon the validity of any experimental model used and its relevance to tuberculosis in humans. In this review, a range of experimental models, from in vitro studies with fast-growing low-pathogenic species of mycobacteria to the infection of nonhuman primates with virulent M. tuberculosis, will be discussed.

History

Publication title

Advances in Applied Microbiology

Volume

71

Editors

Allen I. Laskin; Sima Sariaslani; Geoffrey M. Gadd

Pagination

76-84

ISBN

978-0-12-380993-3

Department/School

Tasmanian School of Medicine

Publisher

Elsevier

Place of publication

United States

Extent

6

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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