University Of Tasmania

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P50 Comparison of the EQ-5D-5L and Aqol-8D in a cohort of people with idiopathic pulmonary fibrosis in Australia

conference contribution
posted on 2023-05-24, 21:38 authored by Ingrid CoxIngrid Cox, Julie CampbellJulie Campbell, Barbara de GraaffBarbara de Graaff, Corte, TJ, Moodley, Y, Hopkins, P, Macansh, S, Eugene WaltersEugene Walters, Andrew PalmerAndrew Palmer

Background: Idiopathic pulmonary fibrosis (IPF) is a debilitating chronic lung disease with a high symptom burden, which has a substantial impact on health-related quality of life (HRQoL). Our study aimed to assess the performance of the EuroQol five-dimension (EQ-5D-5L) and the Assessment of Quality of Life- eight-dimension (AQoL-8D) questionnaires in measuring HRQoL as utility values (HSUVs) in an Australian IPF cohort.

Objectives: Data were collected from participants of the Australian IPF Registry (AIPFR) using self-administered surveys which included the EQ-5D-5L and the AQoL-8D. Clinical data and disease specific HRQoL instruments were collected from the AIPFR. Performance of the two instruments was evaluated based on questionnaire practicality, agreement between the two instruments and test performance (internal and construct validity).

Results: Overall completion rates for the EQ-5D-5L and AQoL-8D were 96% and 85% respectively. Mean (median) HSUVs were 0.65 (0.70) and 0.69 (0.72) for the EQ-5D-5L and AQoL-8D respectively. There was reasonable agreement between the two instruments based on the Bland-Altman plot mean difference (-0.04) and intraclass correlation coefficient (0.84), however there were some differences. A larger range of values was observed with the EQ-5D-5L when compared to the AQOL-8D (-0.57-1.00 vs 0.16-1.00). The EQ-5D-5L had a greater divergent sensitivity and efficacy in relation to assessing HSUVs between clinical groupings. The AQoL-8D however had a higher sensitivity to measure psychosocial aspects of HRQoL in IPF.

Conclusions: The EQ-5D-5L exhibited better performance when compared to AQoL-8D in persons with IPF. This may be attributable to the high symptom burden which is physically debilitating to which the EQ-5D-5L may be more sensitive.


Publication title

The Future of HEOR in Patient-Driven Digital Healthcare Systems


25(7) Supplement


Michael Drummond, C. Daniel Mullins






Menzies Institute for Medical Research



Place of publication

Value in Health

Event title

ISPOR 2022 Conference

Event Venue

Washington D.C

Date of Event (Start Date)


Date of Event (End Date)


Repository Status

  • Restricted

Socio-economic Objectives

Evaluation of health outcomes