338 Screening, recruitment and baseline characteristics of the long-term evaluation of glucosamine sulphate (legs) study participants

Clinical trials evaluating potential ’disease-modifying’ agents for osteoarthritis are required to demonstrate both symptomatic and structural benefit. Ideally, to reduce ceiling or floor effects, study participants are required to have at least moderate pain, yet retain sufficient tibiofemoral joint space to allow the measurement of narrowing over time. To describe study recruitment procedures and baseline demographics of people with symptomatic knee osteoarthritis participating in the Long-term Evaluation of Glucosamine Sulphate (LEGS) study (NCT00513422).