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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

journal contribution
posted on 2023-05-17, 08:09 authored by van Heel, DA, Franke, L, Hunt, KA, Gwilliam, R, Zhernakova, A, Inouye, M, Wapenaar, MC, Barnardo, MCNM, Bethel, G, Holmes, GKT, Feighery, C, Jewell, D, Kelleher, D, Kumar, P, Travis, S, Walters, JRF, Sanders, DS, Howdle, P, Swift, J, Playford, RJ, McLaren, WM, Mearin, ML, Mulder, C J, McManus, R, McGinnis, R, Cardon, LR, Deloukas, P, Wijmenga, C
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 × 10-7) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5′ of IL21; meta-analysis P = 1.3 × 10-14, odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. © 2007 Nature Publishing Group.

History

Publication title

Nature Genetics

Volume

39

Issue

7

Pagination

827-829

ISSN

1061-4036

Department/School

College Office - College of Health and Medicine

Publisher

Nature Publishing Group

Place of publication

345 Park Ave South, New York, USA, Ny, 10010-1707

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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