A new evolutionary algorithm-based home monitoring device for Parkinson's dyskinesia
journal contributionposted on 2023-05-20, 04:29 authored by Lones, MA, Jane AltyJane Alty, Cosgrove, J, Duggan-Carter, P, Jamieson, S, Naylor, RF, Turner, AJ, Smith, SL
Parkinson’s disease (PD) is a neurodegenerative movement disorder. Although there is no cure, symptomatic treatments are available and can significantly improve quality of life. The motor, or movement, features of PD are caused by reduced production of the neurotransmitter dopamine. Dopamine deficiency is most often treated using dopamine replacement therapy. However, this therapy can itself lead to further motor abnormalities referred to as dyskinesia. Dyskinesia consists of involuntary jerking movements and muscle spasms, which can often be violent. To minimise dyskinesia, it is necessary to accurately titrate the amount of medication given and monitor a patient’s movements. In this paper, we describe a new home monitoring device that allows dyskinesia to be measured as a patient goes about their daily activities, providing information that can assist clinicians when making changes to medication regimens. The device uses a predictive model of dyskinesia that was trained by an evolutionary algorithm, and achieves AUC>0.9 when discriminating clinically significant dyskinesia.
Publication titleJournal of Medical Systems
Department/SchoolWicking Dementia Research Education Centre
PublisherSpringer Nature Switzerland
Place of publicationUnited States
Rights statementCopyright 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/