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A recurrent network in the lateral amygdala: a mechanism for coincidence detection

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posted on 2023-05-21, 00:28 authored by Otto JohnsonOtto Johnson, Hou, M, Ponce-Alvarez, A, Gribelyuk, LM, Alphs, HH, Albert Jr, L, Brown, BL, LeDoux, JE, Doyere, V
Synaptic changes at sensory inputs to the dorsal nucleus of the lateral amygdala (LAd) play a key role in the acquisition and storage of associative fear memory. However, neither the temporal nor spatial architecture of the LAd network response to sensory signals is understood. We developed a method for the elucidation of network behavior. Using this approach, temporally patterned polysynaptic recurrent network responses were found in LAd (intra-LA), both in vitro and in vivo, in response to activation of thalamic sensory afferents. Potentiation of thalamic afferents resulted in a depression of intra-LA synaptic activity, indicating a homeostatic response to changes in synaptic strength within the LAd network. Additionally, the latencies of thalamic afferent triggered recurrent network activity within the LAd overlap with known later occurring cortical afferent latencies. Thus, this recurrent network may facilitate temporal coincidence of sensory afferents within LAd during associative learning.

History

Publication title

Frontiers in Neural Circuits

Pagination

1-19

ISSN

1662-5110

Department/School

School of Psychological Sciences

Publisher

Frontiers Research Foundation

Place of publication

Switzerland

Rights statement

© 2008 Johnson, Hou, Ponce-Alvarez, Gribelyuk, Alphs, Albert, Brown, LeDoux and Doyère. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

Repository Status

  • Open

Socio-economic Objectives

Mental health

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