155157 - a review of visualisations of protein fold.pdf (2.57 MB)
A review of visualisations of protein fold networks and their relationship with sequence and function
journal contributionposted on 2023-05-21, 16:09 authored by Janan Sykes, Barbara HollandBarbara Holland, Michael CharlestonMichael Charleston
Proteins form arguably the most significant link between genotype and phenotype. Understanding the relationship between protein sequence and structure, and applying this knowledge to predict function, is difficult. One way to investigate these relationships is by considering the space of protein folds and how one might move from fold to fold through similarity, or potential evolutionary relationships. The many individual characterisations of fold space presented in the literature can tell us a lot about how well the current Protein Data Bank represents protein fold space, how convergence and divergence may affect protein evolution, how proteins affect the whole of which they are part, and how proteins themselves function. A synthesis of these different approaches and viewpoints seems the most likely way to further our knowledge of protein structure evolution and thus, facilitate improved protein structure design and prediction.
Publication titleBiological reviews of the Cambridge Philosophical Society
Department/SchoolSchool of Natural Sciences
PublisherCambridge University Press
Place of publicationLondon
Rights statement© 2022 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License, (https://creativecommons.org/licenses/by/4.0/) which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.