Throughout postnatal life oligodendrocyte progenitor cells proliferate and differentiate into mature myelinating oligodendrocytes in the central nervous system. Neuronal activity is a major external signal controlling this process. Neurotransmitters, or other signalling molecules released in response to neuronal activity, evoke transient increases in intracellular calcium in oligodendrocyte progenitor cells. As calcium can mediate cellular processes, including the transcription of genes involved in oligodendrocyte progenitor cell division and maturation, a rise in intracellular calcium may be a key signal translating changes in neuronal activity into changes in oligodendrocyte progenitor cell behaviour. Here we review recent advances in our understanding of how neuronal activity can evoke calcium signalling in oligodendrocyte progenitor cells.
Funding
National Health & Medical Research Council
History
Publication title
International Journal of Biochemistry and Cell Biology
Volume
77
Issue
Pt A
Pagination
30-34
ISSN
1357-2725
Department/School
Menzies Institute for Medical Research
Publisher
Pergamon-Elsevier Science Ltd
Place of publication
The Boulevard, Langford Lane, Kidlington, Oxford, England, Ox5 1Gb