University Of Tasmania
81694 -Acute elevation of lipids does not alter exercise hemodynamics in healthy men.pdf (188.24 kB)
Download file

Acute elevation of lipids does not alter exercise hemodynamics in healthy men: a randomized controlled study

Download (188.24 kB)
journal contribution
posted on 2023-05-17, 15:09 authored by James SharmanJames Sharman, Holland, DJ, Leano, R, Kostner, KM
OBJECTIVE: Exaggerated exercise blood pressure (BP) predicts mortality. Some studies suggest this could be explained by chronic hyperlipidemia, but whether acute-hyperlipidemia effects exercise BP has never been tested, and was the aim of this study. METHODS: Intravenous infusion of saline (control) and Intralipid were administered over 60 min in 15 healthy men by double-blind, randomized, cross-over design. Brachial and central BP (including, pulse pressure, augmentation pressure and augmentation index), cardiac output and systemic vascular resistance were recorded at rest and during exercise. RESULTS: Compared with control, Intralipid caused significant increases in serum triglycerides, very low density lipoproteins and free fatty acids (p < 0.001 for all). However, there was no significant difference for any exercise hemodynamic variable (p > 0.05 for all). CONCLUSION: Acute-hyperlipidemia does not significantly change exercise hemodynamics in healthy males. Therefore, the association between raised lipids and increased exercise BP is likely due to the chronic effects of hyperlipidemia.


Publication title









Menzies Institute for Medical Research


Elsevier Ireland Ltd

Place of publication


Rights statement

Copyright 2012 Published by Elsevier Ireland Ltd.

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified