Adiponectin sparks an interest in calcium

Adiponectin and its receptors, AdipoR1 and AdipoR2, regulate glucose and fatty acid metabolism via activation of AMP-activated protein kinase. Recent work in Nature (Iwabu et al., 2010) demonstrates that adiponectin induces a marked Ca²⁺ influx in skeletal muscle via AdipoR1 to control mitochondrial biogenesis, reduce oxidative stress, and enhance endurance capacity.