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Administration of DL-2-amino-5-phosphonovaleric acid (AP5) induces transient inhibition of reminder-activated memory retrieval in day-old chicks

journal contribution
posted on 2023-05-16, 12:45 authored by Mathew SummersMathew Summers, Crowe, SF, Ng, KT
DL-2-Amino-5-phosphonovaleric acid (50 μM) administered immediately after a visual reminder presented to day-old chickens between 7.5 min and 24 h following a single trial passive avoidance learning task produced transient losses of memory on retention test, an effect not observed in the absence of a reminder or when the reminder was given 48 h post learning. The duration of the transient deficits decreased with increasing interval between training and the reminder trial. The time of onset of memory loss after the reminder trial appeared to increase with increasing interval between the training and the reminder trials. The results suggest that, for a period of at least up to 24 h after passive avoidance training, retrieval of memory may lead to processes which are sensitive to inhibition by the NMDA receptor antagonist AP5, with the duration of sensitivity post retrieval decreasing as the period of memory consolidation increases. The results extend previously reported findings and suggest the possibility that consolidation of a stable memorial representation of a learning experience may take over several days and may entail the concurrent laying down of a stable retrieval mechanism.

History

Publication title

Cognitive Brain Research

Volume

5

Issue

4

Pagination

311-321

ISSN

0926-6410

Department/School

School of Psychological Sciences

Publisher

Elsevier Science

Place of publication

Amerstdam, Netherlands

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the environmental sciences

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