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Adverse effects of lag filters used for detector baseline noise suppression in HPLC.
journal contribution
posted on 2023-05-26, 11:06 authored by Paul HaddadPaul Haddad, Keating, RW, Low, GKCMost detectors used for High Performance Liquid Chromatography employ a lag filter for suppression of baseline noise. This filter is characterised by its time constant, . At high values of (in excess of 0.5 sec), the lag filter seriously distorts the shape of a chromatographic peak, causing reduced peak heights, altered retention times and increased peak width. These changes result in significantly decreased resolution and decreased plate counts. These effects are investigated quantitatively.
History
Publication title
Journal of Liquid ChromatographyVolume
5Article number
5Number
5Pagination
853-867ISSN
1520-572X (electroic) 1082-6076 (paper)Publication status
- Published
Rights statement
copyright Taylor and FrancisRepository Status
- Restricted