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Age-related differences in corticospinal excitability during a Go/NoGo task
journal contributionposted on 2023-05-17, 08:16 authored by Fujiyama, H, Tandonnet, C, Jeffery SummersJeffery Summers
Age-related slowing of reaction times (RTs) is well documented but whether the phenomenon reflects deficits in movement preparation and/or response generation processes is unclear. To gain further insight into this issue, transcranial magnetic stimulation (TMS) was used to investigate motor cortex (M1) excitability and short-interval intracortical inhibitory (SICI) processes during a Go/NoGo RTtask in younger and older adults. Single- and paired-pulse TMS was delivered over the left M1 during preparation and response generation periods in a right-hand muscle. Younger adults had shorter RTs and a larger increase in corticospinal excitability at response generation period than older adults. SICI modulation for both groups showed a large reduction in inhibition immediately prior to EMGonset. These findings indicate age-related differences in corticospinal excitability during the response generation stage of sensorimotor information processing.
Department/SchoolSchool of Psychological Sciences
PublisherWiley-Blackwell Publishing Inc
Place of publicationUnited Kingdom
Rights statementCopyright © 2011 Society for Psychophysiological Research The definitive published version is available online at: http://www.interscience.wiley.com