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Aliskiren retards the progression of renal disease in diabetes mellitus: an experimental study in rats

journal contribution
posted on 2023-05-18, 04:15 authored by Mohammad, BI, Kareem, ZA, Hadi, NR, Al-Aubaidy, HAM

Objective:This study was undertaken to evaluate the protective effect of aliskiren on renal disease progression in diabetes mellitus. Materials and methods: Twenty-one adult albino rats were randomly divided into 3 groups: the normal control group (NC) injected with citrate buffer,the diabetic control group (DC)injected with streptozotocin (STZ) (60mg/kg I.P), andthe aliskiren treated group (AT),injected with STZ (60mg/kg I.P) and received aliskiren (10 mg/kg orally daily for 8 weeks). At the end of 8th weeks, blood& urine samples were collected for measurements of random blood sugar (RBS), HbA1c, renal function parameters,malondialdehyde (MDA) and reduced glutathione (GSH). Monocyte chemoattractant protein-1 (MCP-1) and histopathological assessment of degree of renal damage also performed.

Results: Compared to DC group, there is a significant decrease in the levels of blood urea (40.1±2.31), uric acid (4.13±0.191), serum creatinine (0.89±0.074), albuminuria (27.4±2.03), andMDA(1.21±0.013) in the ATgroup,(p≤0.05). Expression of renal MCP-1 significantly decreased associated with a significant reduction in glomerular lesion in AT group compared to NC group (p<0.001).

Conclusion: We concluded that aliskiren is helpful in reducing lipid peroxidation, improvingrenal function and reducingrenal expression of inflammatory markers and consequently reduces the progression of diabetic nephropathy.

History

Publication title

World Journal of Pharmaceutical Research: an international peer review journal for science and pharmacy professional

Issue

6

Pagination

1999-2011

ISSN

2277-7105

Department/School

Tasmanian School of Medicine

Publisher

World Journal of Pharmaceutical Research

Place of publication

India

Rights statement

Copyright 2013 World Journal of Pharmaceutical Research

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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