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Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease
Our previous studies have shown that a minor isoform of acetylcholinesterase (AChE) is increased in the cerebrospinal fluid (CSF) of Alzheimer’s disease (AD) patients. In the present study, the glycosylation of butyrycholinesterase (BuChE) was found to be altered in AD CSF. By combining an analysis of CSF AChE and BuChE glycosylation, it is possible to identify cases of AD with more than 90% sensitivity and specificity.
History
Publication title
Brain ResearchVolume
889Issue
1-2Pagination
247-250ISSN
0006-8993Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier BVPlace of publication
NetherlandsRights statement
The definitive version is available at http://www.sciencedirect.comRepository Status
- Restricted