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Alzheimer's disease-like impaired cognition in endothelial-specific megalin-null mice

Version 2 2024-10-28, 04:04
Version 1 2023-05-17, 23:22
journal contribution
posted on 2024-10-28, 04:04 authored by M Dietrich, D Antequera, C Pascual, N Castro, M Bolos, E Carro
Megalin has been suggested to be involved in Alzheimer's disease (AD), mediating blood-brain barrier (BBB) transport of multiple ligands, including amyloid-β peptide (Aβ), but also neuroprotective factors. Because no transgenic model is currently available to study this concept, we have obtained transgenic mice blocking megalin expression at the BBB. These endothelial megalin deficient (EMD) mice developed increased anxiety behavior and impaired learning ability and recognition memory, similar to symptoms described in AD. Degenerating neurons were also observed in the cerebral cortex of EMD mice. In view of our findings we suggest that, in mice, megalin deficiency at the BBB leads to neurodegeneration.

History

Publication title

Journal of Alzheimer'S Disease

Volume

39

Issue

4

Pagination

711-717

ISSN

1387-2877

Department/School

Menzies Institute for Medical Research

Publisher

I O S Press

Publication status

  • Published

Place of publication

Netherlands

Socio-economic Objectives

280102 Expanding knowledge in the biological sciences

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