Alzheimer's disease-like impaired cognition in endothelial-specific megalin-null mice
Version 2 2024-10-28, 04:04Version 2 2024-10-28, 04:04
Version 1 2023-05-17, 23:22Version 1 2023-05-17, 23:22
journal contribution
posted on 2024-10-28, 04:04authored byM Dietrich, D Antequera, C Pascual, N Castro, M Bolos, E Carro
Megalin has been suggested to be involved in Alzheimer's disease (AD), mediating blood-brain barrier (BBB) transport of multiple ligands, including amyloid-β peptide (Aβ), but also neuroprotective factors. Because no transgenic model is currently available to study this concept, we have obtained transgenic mice blocking megalin expression at the BBB. These endothelial megalin deficient (EMD) mice developed increased anxiety behavior and impaired learning ability and recognition memory, similar to symptoms described in AD. Degenerating neurons were also observed in the cerebral cortex of EMD mice. In view of our findings we suggest that, in mice, megalin deficiency at the BBB leads to neurodegeneration.
History
Publication title
Journal of Alzheimer'S Disease
Volume
39
Issue
4
Pagination
711-717
ISSN
1387-2877
Department/School
Menzies Institute for Medical Research
Publisher
I O S Press
Publication status
Published
Place of publication
Netherlands
Socio-economic Objectives
280102 Expanding knowledge in the biological sciences