Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes

<strong>Objective:</strong> To investigate the longitudinal association between objectively measured ambulatory activity (AA) and knee MRI-detected osteophytes (OPs), and to test whether this relationship was modified by common risk factors for OA including sex, obesity, disease severity and knee injury history.<p></p> <p><strong>Methods:</strong> 408 community-dwelling adults aged 51-81 years were assessed at baseline and 2.7 years. T1-weighted fat-suppressed MRI was used to evaluate knee OPs at both time points. AA was assessed at baseline by pedometers and categorized as: less active (≤7499 steps per day), moderately active (7500-9999 steps per day) and highly active (≥10,000 steps per day).</p> <p><strong>Results:</strong> Statistically significant interactions were detected between knee OA risk factors and AA on increases in MRI-detected OPs (all <i>P</i> < 0.05). In stratified analyses, being moderately active, compared to being less active, was protective against an increase in MRI-detected OPs (score change of ≥1) in females (relative risk (RR) = 0.42, 95%CI, 0.25-0.70, <i>P</i> < 0.01), those who were obese (RR = 0.50, 95%CI, 0.30-0.83, <i>P</i> < 0.01), those with radiographic OA (ROA) (RR = 0.68, 95%CI, 0.47-0.97, <i>P</i> = 0.02) and those with a history of knee injury (RR = 0.27, 95%CI, 0.08-0.88, <i>P</i> = 0.02) in almost every knee compartment, after adjustment for confounders. No statistically significant associations were found in males, non-obese, non-ROA or non-injury groups.</p> <p><strong>Conclusions:</strong> Being moderately active is protective against an increase in MRI-detected OPs in females, those with ROA, those who are obese and those with a history of knee injury. These findings suggest that being moderately active is beneficial for individuals who are at higher risk of knee OA.</p>