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An adverse lipid profile is associated with disability and progression in disability, in people with MS
journal contributionposted on 2023-05-18, 01:24 authored by Tettey, P, Steve Simpson JRSteve Simpson JR, Bruce TaylorBruce Taylor, Christopher BlizzardChristopher Blizzard, Ponsonby, A-L, Dwyer, T, Kostner, K, Ingrid van der MeiIngrid van der Mei
BACKGROUND: There is accumulating data suggesting an association between serum lipids, apolipoproteins and disability in multiple sclerosis (MS). OBJECTIVES: To investigate the associations between serum lipids, apolipoproteins and disability in MS. METHODS: A cohort of 178 participants with clinically-definite MS in southern Tasmania, Australia were prospectively followed from 2002 - 2005, and serum samples were obtained at study entry and at each biannual review, to measure lipid profile and apolipoprotein levels. Associations with disability and annual change in disability were evaluated using linear regression and multilevel mixed-effects linear regression. RESULTS: In the unadjusted analyses, nearly all lipid-related variables were positively associated with Expanded Disability Status Scale (EDSS). After adjustment for confounders, total cholesterol (TC) (p = 0.037), apolipoprotein B (ApoB) (p = 0.003), and the apolipoprotein B to apolipoprotein A-I ratio (ApoB/ApoA-I ratio) (p = 0.018) were independently associated with a higher EDSS. Higher body mass index (BMI) was also independently associated with higher EDSS (p = 0.013). With the progression analysis, the total cholesterol to high density lipoprotein (HDL) ratio (TC/HDL ratio) (p = 0.029) was prospectively associated with subsequent change in EDSS. CONCLUSION: In this prospective population-based cohort study, an adverse lipid profile was associated with high levels of MS disability and disease progression. Improving serum lipids may be beneficial for MS patients, to potentially improve clinical outcomes and vascular comorbidities.
Multiple Sclerosis Australia
Publication titleMultiple Sclerosis Journal
Department/SchoolMenzies Institute for Medical Research
PublisherSage Publications Ltd.
Place of publicationUnited Kingdom
Rights statementCopyright 2014 the authors