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Anterior cingulate activity to salient stimuli is modulated by autonomic arousal in Posttraumatic Stress Disorder
journal contribution
posted on 2023-05-17, 07:11 authored by Kim FelminghamKim Felmingham, Williams, LM, Kemp, AH, Rennie, C, Gordon, E, Bryant, RAReduced ventral anterior cingulate (vACC) activity to threat is thought to reflect an impairment in regulating arousal networks in posttraumatic stress disorder (PTSD). Concurrent functional magnetic resonance imaging (fMRI) and skin conductance response (SCR) recording were used to examine neural functioning when arousal networks are engaged. Eleven participants with PTSD and 11 age- and sex-matched non-traumatized controls performed an oddball task that required responding to salient, non-trauma-related auditory target tones embedded in lower frequency background tones. Averaged target-background analyses revealed significantly greater dorsal ACC, supramarginal gyrus, and hippocampal activity in PTSD relative to control participants.With- SCR target responses resulted in increased vACC activity in controls, and dorsal ACC activity in PTSD. PTSD participants had reduced vACC activity relative to controls to target toneswhen SCR responseswere present. This reduction in vACC in PTSD relative to controlswas not apparent inwithout-SCR responses. These findings suggest that a reduction in vACC in PTSD occurs specifically when arousal networks are engaged.
History
Publication title
Psychiatry Research: NeuroimagingVolume
2009Issue
173Pagination
59-62ISSN
0925-4927Department/School
School of Psychological SciencesPublisher
Elsevier Sci Ireland LtdPlace of publication
Customer Relations Manager, Bay 15, Shannon Industrial Estate Co, Clare, IrelandRights statement
The definitive version is available at http://www.sciencedirect.comRepository Status
- Restricted