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Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: a cross-over, randomized, double-blind clinical trial

journal contribution
posted on 2023-05-20, 18:55 authored by do Rosario, VA, Chang, C, Spencer, J, Alahakone, T, Roodenrys, S, Francois, M, Weston-Green, K, Nadine MachaNadine Macha, David NicholsDavid Nichols, Katherine KentKatherine Kent, Williams, D, Wright, IMR, Charlton, K

Background & aims: Postprandial metabolic imbalances are important indicators of later developing cardiovascular disease (CVD). This study investigated the effects of food anthocyanins on vascular and microvascular function, and CVD associated biomarkers following a high fat high energy (HFHE) meal challenge in overweight older adults.

Methods: Sixteen subjects (13 female, 3 male, mean age 65.9 SD 6.0 and body mass index 30.6 kg/m2 SD 3.9) participated in a crossover, randomized, controlled, double-blind clinical trial (registered under Australian New Zealand Clinical Trials Registry, identifier no. ACTRN12620000437965). Participants consumed a HFHE meal with a 250 mL dose of either intervention (anthocyanins-rich Queen Garnet Plum) or control (apricot) juice. Blood samples and blood pressure measures were collected at baseline, 2 h and 4 h following the HFHE meal. Vascular and microvascular function were evaluated at baseline and 2 h after the HFHE meal.

Results: Participants had a higher 2 h postprandial flow-mediated dilatation (+1.14%) and a higher microvascular post-occlusive reactive hyperaemia (+0.10 perfusion units per mmHg) when allocated to the anthocyanin compared to the control arm (P = 0.019 and P = 0.049, respectively). C-reactive protein was lower 4 h postprandially in the anthocyanins (1.80 mg/L, IQR 0.90) vs control arm (2.30 mg/L, IQR 1.95) (P = 0.026), accompanied by a trend for lower concentrations of interleukin-6 (P = 0.075). No significant postprandial differences were observed between treatments for blood pressure, triacylglycerol, total cholesterol, serum derivatives of reactive oxidative metabolites, tumor necrosis factor alpha, interleukin-1 beta, or maximum microvascular perfusion following iontophoresis of acetylcholine.

Conclusion: Fruit-based anthocyanins attenuated the potential postprandial detrimental effects of a HFHE challenge on parameters of vascular and microvascular function, and inflammatory biomarkers in overweight older adults. Anthocyanins may reduce cardiovascular risk associated with endothelial dysfunction and inflammatory responses to a typical high fat 'Western' meal. Further studies are required to better elucidate the clinical implications of postprandial biomarkers of CVD.

History

Publication title

Clinical Nutrition

Volume

40

Pagination

879-889

ISSN

0261-5614

Department/School

Tasmanian Institute of Agriculture (TIA)

Publisher

Churchill Livingstone

Place of publication

Journal Production Dept, Robert Stevenson House, 1-3 Baxters Place, Leith Walk, Edinburgh, Scotland, Midlothian, Eh1 3Af

Rights statement

Copyright 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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