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Antibody response to sheep red blood cells in platypus and echidna

journal contribution
posted on 2023-05-16, 14:51 authored by Wronski, E, Gregory WoodsGregory Woods, Munday, BL
There is limited information regarding the kinetics of antibody responses exhibited by the platypus and the echidna in response to a T cell dependent antigen. In this preliminary study a platypus, an echidna and a rabbit were inoculated with sheep red blood cells to compare their antibody responses and kinetics. The antibody titres, produced by the platypus and echidna, were less than those elicited in the rabbit. Furthermore, the echidna and platypus exhibited a weak secondary response. This was most likely due to a failure of the platypus and echidna to undergo the characteristic IgM to IgG isotype switch following second antigen exposure. The conformational structure of these antibodies may differ from eutherian antibodies. This was further supported by a heat sensitivity experiment that indicated that these antibodies are more labile than rabbit immunoglobulins and therefore structurally less stable. © 2003 Elsevier Inc. All rights reserved.

History

Publication title

Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology

Volume

136

Issue

4

Pagination

957-963

ISSN

1095-6433

Department/School

Tasmanian School of Medicine

Publisher

Elsevier

Place of publication

New York, USA

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the environmental sciences

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