One of the major problems facing the development of capillary electrophoresis (CE) is the relatively high limits of detection when compared to traditional high-performance liquid chromatographic (HPLC) methods. While the use of an alternative detector can offer better sensitivity, a more universal approach is sample preconcentration. Numerous on-line methods have been developed to improve the sensitivity of CE, and are based on electrophoretic principles, chromatographic principles, or a combination of both. This review will discuss all forms of on-line preconcentration methods for CE, with emphasis given to those that have shown particular merit when applied to inorganic and small organic anions.
History
Publication title
Electrophoresis
Volume
22
Article number
12
Number
12
Pagination
2464-2489
ISSN
0173-0835
Publication status
Published
Rights statement
The definitive published version is available online at: http://interscience.wiley.com