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Association between DEFB103 gene copy number variation and ankylosing spondylitis: A case-control study
journal contribution
posted on 2023-05-18, 12:27 authored by Cai, G, Xia, Q, Fan, D, Li, X, Ding, N, Hu, Y, Yang, X, Liu, L, Xin, L, Wang, L, Xu, S, Xu, J, Zou, Y, Chang-Hai DingChang-Hai Ding, Pan, FIn this brief communication, we investigate the role of DEFB103 gene copy number variation (CNV) in ankylosing spondylitis (AS) susceptibility. A total of 807 Chinese individuals including 406 AS patients and 401 controls were enrolled. The DEFB103 copy number was measured by two sets of probes to obtain a stable result in a custom-by-design Multiplex AccuCopy™ kit (Genesky Biotechnologies Inc., Shanghai, China) based on a multiplex fluorescence competitive polymerase chain reaction (PCR) principle. The copy number of DEFB103 ranged from 2 to 6 in both AS patients and controls. Mann–Whitney U test and chi-squared test were performed to analyze the difference of DEFB103 copy number between AS patients and controls while no statistical difference has been found. We considered the copy number of DEFB103 gene may not associate with susceptibility to AS.
History
Publication title
Tissue AntigensVolume
86Pagination
195-198ISSN
0001-2815Department/School
Menzies Institute for Medical ResearchPublisher
Blackwell MunksgaardPlace of publication
35 Norre Sogade, Po Box 2148, Copenhagen, Denmark, Dk-1016Rights statement
Copyright 2015 John Wiley & SonsRepository Status
- Restricted