Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects
METHODS: Searches of Medline, Embase, and ISI Web of Science were conducted up to July 2013. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of association between the GDF5 polymorphism and knee OA risk.
RESULTS: A total of 20 studies with 23,995 individuals were included. There were weak but significant associations present between the GDF5 polymorphism and knee OA at the allele level (C vs. T: OR =0.85, 95% CI =0.80-0.90) and genotype level (CC vs. TT: OR =0.73; CT vs. TT: OR =0.84; CC/CT vs. TT: OR =0.81; CC vs.
CT/TT: OR =0.81) in the overall population. In the subgroup analysis by ethnicity, we observed a strong significant association (OR =0.60 to 0.80, all P <0.05) in Asian population and weaker associations (OR =0.78 to 0.87, all P <0.05) in Caucasian population; however marked heterogeneity was detected in all models except for CC vs. TT (I2 = 12.9%) and CC vs. CT + TT (I2 = 0.0%) in Asians.
CONCLUSIONS: These results strongly suggest that the C allele and CC genotype of the GDF5 gene are protective for knee OA susceptibility across different populations.
Publication titleBMC Musculoskeletal Disorders
Department/SchoolMenzies Institute for Medical Research
PublisherBiomed Central Ltd
Place of publicationMiddlesex House, 34-42 Cleveland St, London, England, W1T 4Lb
Rights statementLicensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/