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Association of body composition and hormonal and inflammatory factors with tibial cartilage volume and sex difference in cartilage volume in young adults

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posted on 2023-05-18, 14:28 authored by Benny Eathakkattu AntonyBenny Eathakkattu Antony, Alison VennAlison Venn, Cicuttini, F, March, L, Christopher BlizzardChristopher Blizzard, Dwyer, T, Cross, M, Graeme JonesGraeme Jones, Chang-Hai DingChang-Hai Ding

Objective To describe the associations between body composition, hormonal and inflammatory factors measured 5 years prior and tibial cartilage volume in young adults and to explore if these factors contribute to the sex difference in tibial cartilage volume.

Methods: Subjects broadly representative of the young adult Australian population (n = 328, aged 31-41 years, female 47.3%) were selected. They underwent T1-weighted fat-suppressed magnetic resonance imaging (MRI) of their knees. Tibial cartilage volume was measured from MRI. Sex hormone binding globulin (SHGB) and testosterone in a subset of females and C-reactive protein (CRP) and fibrinogen in both sexes were measured 5 years prior. Body mass index (BMI), fat mass and lean mass were calculated from height, weight and skinfolds.

Results: In multivariable analyses, correlates of tibial cartilage volume included lean body mass (β = 26.4 mm3; 95% confidence interval [95% CI] 13.6, 39.1), fat mass (β = −11.8 mm3; 95% CI −22.2, −1.4), and fibrinogen (β = − 146.4 mm3; 95% CI −276.4, −16.4), but not BMI, testosterone, or CRP level. In women, SHBG was positively associated with tibial cartilage volume (β = 0.67 mm3; 95% CI 0.14, 1.20) and Free Androgen Index was negatively associated with lateral tibial cartilage volume (β = −0.04 mm3; 95% CI −0.07, 0.00). Men had 13% more tibial cartilage volume (500 mm3) than women. The magnitude of this association decreased by 38%, 20%, and 37% after adjustment for lean body mass, fat mass, and fibrinogen, respectively.

Conclusion: Body composition, sex hormones and fibrinogen correlate with knee cartilage volume in young adult life. Sex difference in knee cartilage volume is contributed largely by variations in body composition and/or fibrinogen.

Funding

Arthritis Australia

History

Publication title

Arthritis Care & Research

Volume

68

Issue

4

Pagination

517-525

ISSN

2151-464X

Department/School

Menzies Institute for Medical Research

Publisher

John Wiley & Sons

Place of publication

United States

Rights statement

Copyright 2015 American College of Rheumatology

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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