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150425 - Association of body mass index in youth with adult cardiometabolic risk.pdf (342.57 kB)

Association of body mass index in youth with adult cardiometabolic risk

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posted on 2023-05-21, 08:25 authored by Feitong WuFeitong Wu, Juonala, M, Sabin, MA, Marie-Jeanne Buscot, Pahkala, K, Kylie SmithKylie Smith, Hutri-Kahonen, N, Kahonen, M, Laitinen, TP, Viikari, JSA, Raitakari, OT, Costan Magnussen

BACKGROUND: Whether long‐term exposure to overweight or obesity from early life to adulthood has a detrimental influence on health outcomes is unknown. We aimed to investigate whether duration of overweight or obesity from youth to adulthood is associated with adult cardiometabolic risk.

METHODS AND RESULTS: A population‐based cohort study was performed of 1268 youths, aged 3 to 18 years, with follow‐ups at 3, 6, 9, 12, 21, 27, and 31 years. Duration of overweight or obesity over 31‐year follow‐up was calculated. Adulthood outcomes included type 2 diabetes mellitus, impaired fasting glucose, high insulin levels, high carotid intima‐media thickness, hypertension, low high‐density lipoprotein cholesterol, high low‐density lipoprotein cholesterol and triglycerides, arterial pulse wave velocity, carotid artery compliance, Young elastic modulus, and stiffness index. Rates of overweight/obesity were 7.9% at baseline and 55.9% after 31 years. After adjustment for confounders, longer duration of overweight or obesity was associated with increased risk of all outcomes (relative risk ranged from 1.45–9.06 for type 2 diabetes mellitus, impaired fasting glucose, carotid intima‐media thickness, hypertension, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, and triglycerides; β from 0.370–0.543 m/s for pulse wave velocity; –0.193 to –0.237 %/10 mm Hg for carotid artery compliance; 52.1–136.8 mm Hg·mm for Young elastic modulus; and 0.554–0.882 for stiffness index). When body mass index was further adjusted, these associations disappeared or were substantially reduced. Detrimental associations of adult body mass index with all outcomes were robust to adjustment for confounders and duration of overweight or obesity.

CONCLUSIONS: Overweight or obesity in adulthood rather than childhood appears to be more important for adult cardiometabolic health.


National Health & Medical Research Council


Publication title

Journal of the American Heart Association





Article number







Menzies Institute for Medical Research


Wiley-Blackwell Publishing, Inc.

Place of publication

United States

Rights statement

© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License, ( which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Repository Status

  • Open

Socio-economic Objectives

Overweight and obesity; Preventive medicine

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