Association of brachial-cuff excess pressure with carotid intima-media thickness in Australian adults: a cross-sectional study
Methods: The RP and XSP were derived from brachial volumetric waveforms measured using cuff oscillometry (SphygmoCor XCEL) in 1691 mid-life adults from the CheckPoint study (a population-based cross-sectional study nested in the Longitudinal Study of Australian Children). Carotid intima--media thickness (carotid IMT, n = 1447) and carotid--femoral pulse wave velocity (PWV, n = 1632) were measured as preclinical phenotypes of cardiovascular risk. Confounders were conventional risk factors that were correlated with both exposures and outcomes or considered as physiologically important.
Results: There was a modest association between XSP and carotid IMT (β = 0.76 μm, 95% CI, 0.25-1.26 partial R2 = 0.8%) after adjusting for age, sex, BMI, heart rate, smoking, diabetes, high-density lipoprotein cholesterol and mean arterial pressure. Neither RP nor XSP were associated with PWV in the similarly adjusted models (β = -0.47 cm/s, 95% CI, -1.15 to 0.20, partial R2 = 0.2% for RP, and β = 0.04 cm/s, 95% CI, -0.59 to 0.67, partial R2 = 0.01% for XSP).
Conclusion: Cuff-based XSP associates with carotid IMT independent of conventional risk factors, including traditional BP, but the association was weak, indicating that further investigation is warranted to understand the clinical significance of reservoir pressure parameters.
History
Publication title
Journal of HypertensionVolume
38Issue
4Pagination
723-730ISSN
0263-6352Department/School
Menzies Institute for Medical ResearchPublisher
Lippincott Williams & WilkinsPlace of publication
530 Walnut St, Philadelphia, USA, Pa, 19106-3621Rights statement
Copyright 2020 Wolters Kluwer Health, Inc.Repository Status
- Restricted