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134057 - Association of hearing impairment with incident depressive symptoms - Final author version.pdf (223.08 kB)

Association of hearing impairment with incident depressive symptoms: a community-based prospective study

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posted on 2023-05-20, 05:47 authored by Lisan, Q, van Sloten, TT, Lemogne, C, Offredo, L, Rachel ClimieRachel Climie, Boutouyrie, P, Guibout, C, Thomas, F, Danchin, N, Jouven, X, Empana, J-P
Objective: The aim was to investigate the potential association between hearing impairment and incident depressive symptoms.

Methods: Using a prospective community-based cohort study in France (the Paris Prospective Study III), participants aged 50-75 years were recruited between 2008 and 2012 and thereafter followed up every 2 years up to 2018. Hearing impairment, measured at study recruitment by audiometry testing, was defined as a pure tone average >25 decibels in the better ear. Incident depressive symptoms, measured using the validated 13-item Questionnaire of Depression 2nd version, was assessed during follow-up. Multivariate generalized estimating equations were used to compute odds ratio (OR) and 95% confidence intervals (CI).

Results: Among 7591 participants free of depressive symptoms at baseline (mean age 59.8 years, 63% of men), 14.3% had hearing impairment. Over 6 years of follow-up, 479 subjects (6.3%) had incident depressive symptoms. The OR for incident depressive symptoms was 1.36 for subjects with baseline hearing impairment (95% CI, 1.06-1.73). A pooled analysis of 4 published prospective studies yielded a multivariable relative risk of baseline hearing impairment for incident depressive symptoms of 1.29 (95% CI, 1.09-1.53).

Conclusions: In this community-based prospective cohort study of participants aged 50 to 75 years, baseline hearing impairment was associated with a 36% increased odds of incident depressive symptoms.


Publication title

American Journal of Medicine










Menzies Institute for Medical Research


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Clinical health not elsewhere classified

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