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Association of pain phenotypes with risk of falls and incident fractures

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posted on 2023-05-21, 14:54 authored by Maxim Devine, Canchen Ma, Jing TianJing Tian, Benny Eathakkattu AntonyBenny Eathakkattu Antony, Cicuttini, F, Graeme JonesGraeme Jones, Feng PanFeng Pan
Objectives:To compare whether falls risk score and incident fracture over 10.7 years were different among three previously identified pain phenotypes.

Methods:Data on 915 participants (mean age 63 years) from a population-based cohort study were studied at baseline and follow-ups at 2.6, 5.1 and 10.7 years. Three pain phenotypes were previously identified using the latent class analysis: Class 1: high prevalence of emotional problems and low prevalence of structural damage; Class 2: high prevalence of structural damage and low prevalence of emotional problems; Class 3: low prevalence of emotional problems and low prevalence of structural damage. Fractures were self-reported and falls risk score was measured using the Physiological Profile Assessment. Generalized estimating equations model and linear mixed-effects model were used to compare differences in incident fractures and falls risk score over 10.7 years between pain phenotypes, respectively.

Results:There were 3 new hip, 19 vertebral, and 121 non-vertebral fractures, and 138 any site fractures during 10.7-year follow-up. Compared with Class 3, Class 1 had a higher risk of vertebral (relative risk (RR) = 2.44, 95%CI: 1.22–4.91), non-vertebral fractures (RR = 1.20, 95%CI: 1.01–1.42), and any site fractures (RR = 1.24, 95%CI: 1.04–1.46) after controlling for covariates, bone mineral density and falls risk score. Class 2 had a higher risk of non-vertebral and any site fracture relative to those in Class 3 (non-vertebral: RR = 1.41, 95%CI: 1.17–1.71; any site: RR = 1.44, 95%CI: 1.20–1.73), but not vertebral fracture. Compared with Class 3, Class 1 had a higher falls risk score at baseline (β = 0.16, 95%CI: 0.09–0.23) and over 10.7-year (β = 0.03, 95%CI: 0.01–0.04).

Conclusions: Class 1 and/or Class 2 had a higher risk of incident fractures and falls risk score than Class 3, highlighting that targeted preventive strategies for fractures and falls are needed in pain population.

Funding

National Health & Medical Research Council

History

Publication title

Biomedicines

Volume

10

Issue

11

Article number

2924

Number

2924

Pagination

1-9

ISSN

2227-9059

Department/School

Menzies Institute for Medical Research

Publisher

MDPI AG

Place of publication

Switzerland

Rights statement

© 2022. The Authors. Licensee MDPI, Basel, Switzerland. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Repository Status

  • Open

Socio-economic Objectives

Prevention of human diseases and conditions; Clinical health not elsewhere classified; Determinants of health

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