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Association of the active and passive components of left atrial deformation with left ventricular function
Methods: Echocardiography was undertaken in a community-based study of 576 participants ≥ 65 years of age with one or more risk factors (e.g., hypertension, diabetes mellitus, obesity). Strain analysis was conducted using a dedicated software package, using R-R gating. LV function was classified as normal in the presence of global longitudinal strain (GLS) (≤ -18%) or global circumferential strain (GCS) (≤ -22%). The associations between GLS or GCS and LA reservoir, conduit, and pump strain were assessed using univariate and multivariate linear regression.
Results: Patients (mean age 71 ± 5 years, 54% women) with reduced GLS had higher blood pressure and rates of diabetes and obesity (P < .05). LA reservoir strain and conduit strain were lower in the group with impaired GLS (38.2 ± 7.3% vs 39.9 ± 6.4% [P = .004] and 18.7 ± 5.7% vs 20.5 ± 5.1% [P < .001], respectively), but there was no difference in LA pump strain (19.5 ± 5.5% vs 19.3 ± 4.6%, P = .72). GLS was independently associated with LA reservoir and conduit strain (P < .05) but not independently associated with LA pump strain (P = .91). Reduced GCS was associated with a larger body mass index, male sex, and diabetes (P < .05). There were no differences in LA reservoir, conduit, and pump strain in patients with normal and abnormal GCS (P > .05).
Conclusions: The application of LA strain is specific to the component measured. LA pump strain is independent of LV mechanics.
History
Publication title
Journal of the American Society of EchocardiographyVolume
30Issue
7Pagination
659-666ISSN
0894-7317Department/School
Menzies Institute for Medical ResearchPublisher
MosbyPlace of publication
Inc, 11830 Westline Industrial Dr, St Louis, USA, Mo, 63146-3318Rights statement
Copyright 2017 by the American Society of Echocardiography.Repository Status
- Restricted