University of Tasmania
154247 - Associations between Covid 19.pdf (1.35 MB)

Associations between COVID-19 and hospitalisation with respiratory and non-respiratory conditions: a record linkage study

Download (1.35 MB)
journal contribution
posted on 2023-05-21, 14:53 authored by Rowe, SL, Leder, K, Dyson, K, Sundaresan, L, Wollersheim, D, Lynch, B, Abdullahi, I, Cowie, BC, Nicola StephensNicola Stephens, Nolan, TM, Sullivan, SG, Sutton, B, Cheng, AC
Objectives: To assess associations between SARS-CoV-2 infection and the incidence of hospitalisation with selected respiratory and non-respiratory conditions in a largely SARS-CoV-2 vaccine-naive population .

Design, setting, participants: Self-control case series; analysis of population-wide surveillance and administrative data for all laboratory-confirmed COVID-19 cases notified to the Victorian Department of Health (onset, 23 January 2020 - 31 May 2021; ie, prior to widespread vaccination rollout) and linked hospital admissions data (admission dates to 30 September 2021).

Main outcome measures: Hospitalisation of people with acute COVID-19; incidence rate ratios (IRRs) comparing incidence of hospitalisations with defined conditions (including cardiac, cerebrovascular, venous thrombo-embolic, coagulative, and renal disorders) from three days before to within 89 days of onset of COVID-19 with incidence during baseline period (60-365 days prior to COVID-19 onset).

Results: A total of 20 594 COVID-19 cases were notified; 2992 people (14.5%) were hospitalised with COVID-19. The incidence of hospitalisation within 89 days of onset of COVID-19 was higher than during the baseline period for several conditions, including myocarditis and pericarditis (IRR, 14.8; 95% CI, 3.2-68.3), thrombocytopenia (IRR, 7.4; 95% CI, 4.4-12.5), pulmonary embolism (IRR, 6.4; 95% CI, 3.6-11.4), acute myocardial infarction (IRR, 3.9; 95% CI, 2.6-5.8), and cerebral infarction (IRR, 2.3; 95% CI, 1.4-3.9).

Conclusions: SARS-CoV-2 infection is associated with higher incidence of hospitalisation with several respiratory and non-respiratory conditions. Our findings reinforce the value of COVID-19 mitigation measures such as vaccination, and awareness of these associations should assist the clinical management of people with histories of SARS-CoV-2 infection.


Publication title

Medical Journal of Australia






Tasmanian School of Medicine


John Wiley & Sons, Inc.

Place of publication


Rights statement

© 2022 The Author(s). Medical journal of Australia published by John Wiley & Sons Australia, Ltd on behalf of AMPCo Pty Ltd. This is an open access article under the terms of the Creative Commons Attribution 4.0 International License, (CC BY 4.0)

Repository Status

  • Open

Socio-economic Objectives

Public health (excl. specific population health) not elsewhere classified

Usage metrics

    University Of Tasmania


    Ref. manager