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Associations between knee effusion-synovitis and joint structural changes in patients with knee osteoarthritis

journal contribution
posted on 2023-05-19, 12:30 authored by Wang, X, Jin, X, Christopher BlizzardChristopher Blizzard, Benny Eathakkattu AntonyBenny Eathakkattu Antony, Han, W, Zhu, Z, Cicuttini, F, Wluka, AE, Tania WinzenbergTania Winzenberg, Graeme JonesGraeme Jones, Chang-Hai DingChang-Hai Ding
Objective: To describe the associations between effusion-synovitis and joint structural abnormalities in patients with knee osteoarthritis (OA) over 24 months.

Methods: A posthoc analysis using data from a randomized controlled trial in 413 patients with symptomatic OA (aged 63 ± 7 yrs, 208 women). Knee effusion-synovitis volume and score, cartilage defects, cartilage volume, and bone marrow lesions (BML) were assessed using magnetic resonance imaging. Joint space narrowing (JSN) and osteophytes were assessed using radiograph. Least significant change criterion was used to define change in effusion-synovitis volume. Knee symptoms were assessed by Western Ontario and McMaster University OA Index. Multivariable linear/logistic regression and multilevel generalized mixed-effects models were used in longitudinal analyses.

Results: Total effusion-synovitis volume increased modestly from baseline (8.0 ± 8.5 ml) to followup (9.0 ± 10.5 ml). Baseline BML, cartilage defect, JSN, and osteophyte scores were positively associated with change in effusion-synovitis volume (p < 0.05). Baseline cartilage defects and JSN were also associated with change in effusion-synovitis score (p < 0.05). However, neither baseline effusion-synovitis score nor volume consistently predicted change in the above structures except cartilage volume. In the mixed-effects models, knee effusion-synovitis was positively associated with BML (volume: β = 1.19 ml/grade; score: OR = 1.75/grade) and cartilage defects (volume: β = 1.87 ml/grade; score: OR = 2.22/grade), while negatively associated with cartilage volume loss. Change in effusion-synovitis volume was positively correlated with changes in knee pain and stiffness scores (p < 0.05).

Conclusion: Knee cartilage and subchondral bone abnormalities predicted change in effusion-synovitis, but effusion-synovitis did not predict knee structural changes. These findings suggest that synovial inflammation is likely the result of joint structural abnormalities in established OA.

History

Publication title

Journal of Rheumatology

Volume

44

Issue

11

Pagination

1644-1651

ISSN

0315-162X

Department/School

Menzies Institute for Medical Research

Publisher

J Rheumatol Publ Co

Place of publication

920 Yonge St, Suite 115, Toronto, Canada, Ontario, M4W 3C7

Rights statement

The Journal of Rheumatology Copyright © 2017

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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