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Associations between systemic bone mineral density, knee cartilage defects and bone marrow lesions in patients with knee osteoarthritis
Method: One hundred and eight-five subjects with symptomatic knee OA were included in this study. T2-weighted fast spin echo magnetic resonance imaging was used to assess knee cartilage defects and BMLs. Total body, hip and spine BMD were measured using dual-energy X-ray absorptiometry.
Results: After adjustment for potential confounders, total hip BMD was negatively associated with medial tibial cartilage defects, lateral femoral cartilage defects, medial tibial BMLs and lateral tibial BMLs. Spine and total body BMD were negatively associated with lateral femoral cartilage defects, but not with BMLs.
Conclusion: We concluded that BMD particularly at the hip was negatively associated with knee cartilage defects and BMLs.
Publication titleInternational Journal of Rheumatic Diseases
Department/SchoolMenzies Institute for Medical Research
PublisherWiley-Blackwell Publishing Asia
Place of publicationAustralia
Rights statement© 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd