University of Tasmania
Browse

File(s) not publicly available

Associations of birth weight with ocular biometry, refraction, and glaucomatous endophenotypes: The australian twins eye study

journal contribution
posted on 2023-05-18, 03:43 authored by Sun, C, Ponsonby, AL, Brown, Shayne, Kearns, LS, MacKinnon, JR, Barbour, JM, Ruddle, JB, Alexander HewittAlexander Hewitt, Wright, MJ, Martin, NG, Terry DwyerTerry Dwyer, David MackeyDavid Mackey
Purpose: To examine the relationship of birth weight with ocular measures in a Caucasian twin population. Design Cross-sectional study of 1498 twins (308 monozygotic and 441 dizygotic pairs) aged between 5 to 80 years participating in the Australian Twins Eye Study. Methods All participants underwent ophthalmic examination including bilateral cycloplegic autorefraction, keratometry, interpupillary distance (IPD), central corneal thickness, intraocular pressure (IOP), and retinal photography. Birth weight and gestation were obtained from a self-administered questionnaire. A subset of the twins also participated in the Tasmanian Infant Health Study (288) and the Childhood Blood Pressure Study (184), which collected data on birth parameters allowing for verification of data. Linear mixed models were used for the main analysis. Results Both the within-pair (βw 0.27, 95% confidence interval [CI] 0.15, 0.38 mm per kg increase in birth weight, P < .001) and between-pair associations (βB 0.22, 95% CI 0.08, 0.35, P = .002) of birth weight with axial length were significant and of similar magnitude (difference in effect, P = .56), after adjusting for relevant confounders. In contrast, birth weight was negatively associated with corneal curvature (βw -0.82, 95% CI -1.09, -0.55 diopters per kg increase; βB -0.69, 95% CI -0.98, -0.41, both P < .001). These associations remained significant within dizygotic and monozygotic pairs. Refraction, anterior chamber depth, IPD, IOP, and optic disc parameters are unrelated to birth weight. Conclusions Consistent with previous studies in singleton children, lower birth weight is associated with shorter axial length and more curved corneas in this twin study. This also adds new insights into the emmetropization process.

History

Publication title

American Journal of Ophthalmology

Volume

150

Issue

6

Pagination

909-916

ISSN

0002-9394

Department/School

Menzies Institute for Medical Research

Publisher

Elsevier Science Inc

Place of publication

360 Park Ave South, New York, USA, Ny, 10010-1710

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC