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At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family

Version 2 2024-09-17, 02:07
Version 1 2023-05-16, 11:34
journal contribution
posted on 2023-05-16, 11:34 authored by McKay, JD, Williamson, J, Lesueur, F, Stark, M, Duffield, A, Canzian, F, Romeo, G, Hoffman, L
Recent studies have mapped two susceptibility loci which appear to account for familial multinodular goitre (MNG1) and a variant of familial papillary thyroid cancer (PTC), with associated multinodular goitre (TCO). A Tasmanian family (Tas1) has been identified with an autosomal dominant form of PTC. This study has examined the MNG1 and TCO loci to determine if they are similarly predisposing the Tas1 family to PTC. Linkage analysis using identical microsatellite markers described in the two previous studies was used to determine the significance of these loci in the Tasmanian family. The resultant LOD scores were sufficiently negative using multipoint parametric analysis to exclude these two loci from involvement in the Tasmanian family. In addition, six candidate genes, RET, TRK, MET, TSHR, APC and PTEN were also excluded as susceptibility genes in Tas1 by using microsatellites that are positioned in or in close proximity to these genes. These results suggest that there are at least three susceptibility genes that predispose families to familial PTC.

History

Publication title

European Journal of Endocrinology

Volume

141

Pagination

122-125

ISSN

0804-4643

Department/School

Tasmanian School of Medicine

Publisher

Scandinavian University Press

Place of publication

Norway

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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