126382 - Auditory Tones and Foot-Shock.PDF (1.93 MB)
Auditory tones and foot-shock recapitulate spontaneous sub-threshold activity in basolateral amygdala principal neurons and interneurons
journal contribution
posted on 2023-05-19, 18:41 authored by Windels, F, Yan, S, Stratton, PG, Sullivan, R, James CraneJames Crane, Sah, PIn quiescent states such as anesthesia and slow wave sleep, cortical networks show slow rhythmic synchronized activity. In sensory cortices this rhythmic activity shows a stereotypical pattern that is recapitulated by stimulation of the appropriate sensory modality. The amygdala receives sensory input from a variety of sources, and in anesthetized animals, neurons in the basolateral amygdala (BLA) show slow rhythmic synchronized activity. Extracellular field potential recordings show that these oscillations are synchronized with sensory cortex and the thalamus, with both the thalamus and cortex leading the BLA. Using whole-cell recording in vivo we show that the membrane potential of principal neurons spontaneously oscillates between up- and down-states. Footshock and auditory stimulation delivered during down-states evokes an up-state that fully recapitulates those occurring spontaneously. These results suggest that neurons in the BLA receive convergent input from networks of cortical neurons with slow oscillatory activity and that somatosensory and auditory stimulation can trigger activity in these same networks.
History
Publication title
PLoS oneVolume
11Issue
5Article number
e0155192Number
e0155192Pagination
1-14ISSN
1932-6203Department/School
Tasmanian School of MedicinePublisher
Public Library of SciencePlace of publication
United StatesRights statement
Copyright 2016 Windels et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/Repository Status
- Open