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B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
journal contributionposted on 2023-05-18, 12:47 authored by Azuma, T, Yao, S, Zhu, G, Andrew FliesAndrew Flies, Flies, SJ, Chen, L
B7-H1 is an immunoglobulin-like immune suppressive molecule broadly detectable on the majority of human and rodent cancers, and its functions have been attributed to delivering an inhibitory signal to its counter-receptor programmed death-1 (PD-1) on T cells. Here we report that B7-H1 on cancer cells receives a signal from PD-1 to rapidly induce resistance against T cell-mediated killing because crippling signaling capacity of B7-H1 but not PD-1 ablates this resistance. Importantly, loss of B7-H1 signaling is accompanied by increased susceptibility to immune-mediated tumoricidal activity. In addition to resistance against T-cell destruction, B7-H1 cancer cells also become refractory to apoptosis induced by Fas ligation or the protein kinase inhibitor Staurosporine. Our study reveals a new mechanism by which cancer cells use a receptor on immune cells as a ligand to induce resistance to therapy.
Department/SchoolMenzies Institute for Medical Research
PublisherAmerican Society of Hematology
Place of publicationUnited States
Rights statementCopyright 2008 The American Society of Hematology