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B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells
journal contributionposted on 2023-05-18, 12:20 authored by Luo, L, Chapoval, AL, Flies, DB, Zhu, G, Hirano, F, Wang, W, Lau, JS, Dong, H, Tamada, K, Andrew FliesAndrew Flies, Liu, Y, Chen, L
B7-H3 is a B7 family molecule with T cell costimulatory function in vitro. The in vivo role of B7-H3 in the stimulation of tumor immunity is unclear. We report here that expression of B7-H3 by transfection of the mouse P815 tumor line enhances its immunogenicity, leading to the regression of tumors and amplification of a tumor-specific CD8+ CTL response in syngeneic mice. Tumor cells engineered to express B7-H3 elicit a rapid clonal expansion of P1A tumor Ag-specific CD8+ CTL in lymphoid organs in vivo and acquire the ability to directly stimulate T cell growth, division, and development of cytolytic activity in vitro. Our results thus establish a role for B7-H3 in the costimulation of T cell immune responses in vivo.
Publication titleJournal of Immunology
Department/SchoolMenzies Institute for Medical Research
PublisherAmer Assoc Immunologists
Place of publicationUnited States
Rights statement© 2004 by The American Association of Immunologists, Inc.