University Of Tasmania
2016, Journal of Pulmonary & Respiratory Medicine.pdf (322.54 kB)

Bacterial lung disease and COPD

Download (322.54 kB)
journal contribution
posted on 2023-05-18, 21:39 authored by Gautam, SS, O'Toole, RF
Pneumonia is the single largest infectious cause of death in young children worldwide and a major cause of mortality in the elderly. Tuberculosis (TB) is the leading cause of mortality due to respiratory infection worldwide, killing approximately 1.5 million people each year. It is perhaps not surprising that the bulk of applied research on these high burden diseases has focussed on the development of new vaccines, diagnostic tools, and therapeutic interventions. However, in recent years, it has become apparent that both transmissible diseases contribute to the development of a major non-communicable disease, namely, chronic obstructive pulmonary disease (COPD). The latter chronic illness is emerging as the third largest cause of human mortality worldwide after heart disease and stroke and hence, there is increasing interest in understanding its genesis and development. In this review, we examine the evidence that previous lower respiratory tract infectious disease is a contributory factor in the development of COPD. Based on the available data, there is an apparent epidemiological association between pneumonia, TB and COPD in later life. In addition, elements of COPD treatment place patients at a higher risk of presenting with pneumonia or TB. There is now a need to generate a deeper understanding of the interactions between bacterial lung disease and COPD from which new, complementary preventive and co-management strategies can be designed.


Publication title

Journal of Pulmonary & Respiratory Medicine



Article number









Tasmanian School of Medicine


Omics Publishing Group

Place of publication

United States

Rights statement

Copyright: © 2016 Gautam SS, et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania