University of Tasmania
Browse

File(s) under permanent embargo

Barriers and enablers to patient recruitment for randomised controlled trials on treatment of chronic wounds: a systematic review

journal contribution
posted on 2023-05-20, 01:47 authored by Bugeja, L, Low, JK, McGinnes, RA, Team, V, Sankar SinhaSankar Sinha, Weller, C
Randomised controlled trials represent the gold standard in intervention efficacy evaluation. However, suboptimal recruitment affects completion and the power of a therapeutic trial in detecting treatment differences. We conducted a systematic review to examine the barriers and enablers to patient recruitment for randomised controlled trials on chronic wound treatment. Review registration was under PROSPERO 2017:CRD42017062438. We conducted a systematic search of Ovid MEDLINE, EBSCOhost CINAHL, Ovid Cochrane Library, Ovid EMBASE, and Ovid PsycINFO databases in June 2017 for chronic wound treatment randomised controlled trials. Twenty-seven randomised controlled trials or qualitative studies met the inclusion criteria. Among the 24 randomised controlled trials, 21 were assessed as low quality in relation to recruitment, and 3 were assessed as high quality. All 27 studies reported barriers to recruitment in chronic wound randomised controlled trials. The reported barriers to recruitment were: study-related, patient-related, clinician-related, health system-related, and/or operational-related. No study reported recruitment enablers. To enhance randomised controlled trial recruitment, we propose the need for improved integration of research and clinical practice. To alleviate the problems arising from inadequate reporting of randomised controlled trials, the Consolidated Standards of Reporting Trials Statement could include an additional item on recruitment barriers. This approach will allow for increased awareness of the potential barriers to recruitment for Randomised controlled trials (RCTs) in both wound management and other health care research.

History

Publication title

International Wound Journal

Volume

15

Issue

6

Pagination

880-892

ISSN

1742-4801

Department/School

Tasmanian School of Medicine

Publisher

Blackwell Publishing Ltd

Place of publication

United Kingdom

Rights statement

Copyright 2018 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Repository Status

  • Restricted

Socio-economic Objectives

Treatment of human diseases and conditions

Usage metrics

    University Of Tasmania

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC