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Behavioral, metabolic, and lipidomic characterization of the 5xFADxTg30 mouse model of Alzheimer’s disease
journal contributionposted on 2024-02-02, 03:54 authored by JPS Marshall, K Huynh, GI Lancaster, J Ng, JM Collins, G Pernes, A Liang, T Featherby, NA Mellet, BG Drew, AC Calkin, Anna KingAnna King, PJ Meikle, MA Febbraio, PA Adlard, Darren HenstridgeDarren Henstridge
Alzheimer's disease (AD) is associated with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles (NFT). We characterized the behavioral, metabolic and lipidomic phenotype of the 5xFADxTg30 mouse model which contains overexpression of both Aβ and tau. Our results independently reproduce several phenotypic traits described previously for this model, while providing additional characterization. This model develops many aspects associated with AD including frailty, decreased survival, initiation of aspects of cognitive decline and alterations to specific lipid classes and molecular lipid species in the plasma and brain. Notably, some sex-specific differences exist in this model and motor impairment with aging in this model does compromise the utility of the model for some movement-based behavioral assessments of cognitive function. These findings provide a reference for individuals interested in using this model to understand the pathology associated with elevated Aβ and tau or for testing potential therapeutics for the treatment of AD.
Department/SchoolHealth Sciences, Wicking Dementia Research Education Centre
- Published online
Place of publicationUnited States
Rights statement© 2024 The Author(s). Licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license https://creativecommons.org/licenses/by-nc-nd/4.0/
3101 Biochemistry and Cell Biology31 Biological SciencesAlzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)Alzheimer's DiseaseNeurodegenerativeAcquired Cognitive ImpairmentBrain DisordersNeurosciencesBehavioral and Social ScienceDementiaAging2 Aetiology2.1 Biological and endogenous factorsNeurological