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Beta-1 Integrin Is Not Essential for Hematopoiesis but Is Necessary for the T Cell-Dependent IgM Antibody Response
journal contributionposted on 2023-05-17, 07:45 authored by Brakebusch, C, Fillatreau, S, Potocnik, AJ, Bungartz, G, Wilhelm, P, Svensson, M, Kearney, P, Heinrich KornerHeinrich Korner, Gray, D, Fassler, R
Several experimental evidences suggested that Î²1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the Î²1 integrin gene restricted to the hematopoietic system, we show that Î²1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that Î²1 integrins are necessary for the primary IgM antibody response.
Department/SchoolMenzies Institute for Medical Research
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