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Beta-1 Integrin Is Not Essential for Hematopoiesis but Is Necessary for the T Cell-Dependent IgM Antibody Response
journal contribution
posted on 2023-05-17, 07:45 authored by Brakebusch, C, Fillatreau, S, Potocnik, AJ, Bungartz, G, Wilhelm, P, Svensson, M, Kearney, P, Heinrich KornerHeinrich Korner, Gray, D, Fassler, RSeveral experimental evidences suggested that β1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the β1 integrin gene restricted to the hematopoietic system, we show that β1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that β1 integrins are necessary for the primary IgM antibody response.
History
Publication title
ImmunityVolume
16Pagination
465-477ISSN
1074-7613Department/School
Menzies Institute for Medical ResearchPublisher
Cell PressPlace of publication
1100 Massachusetts Ave, Cambridge, USA, Ma, 02138Repository Status
- Restricted