Bile salts in chiral micellar electrokinetic chromatography: 2000-2020
journal contribution
posted on 2023-05-21, 12:38authored byRaymond Fernando Yu, Joselito Quirino
Bile salts are naturally occurring chiral surfactants that are able to solubilize hydrophobic compounds. Because of this ability, bile salts were exploited as chiral selectors added to the background solution (BGS) in the chiral micellar electrokinetic chromatography (MEKC) of various small molecules. In this review, we aimed to examine the developments in research on chiral MEKC using bile salts as chiral selectors over the past 20 years. The review begins with a discussion of the aggregation of bile salts in chiral recognition and separation, followed by the use of single bile salts and bile salts with other chiral selectors (i.e., cyclodextrins, proteins and single-stranded DNA aptamers). Advanced techniques such as partial-filling MEKC, stacking and single-drop microextraction were considered. Potential applications to real samples, including enantiomeric impurity analysis, were also discussed.
History
Publication title
Molecules
Volume
26
Issue
18
Pagination
1-24
ISSN
1420-3049
Department/School
School of Natural Sciences
Publisher
Basel
Place of publication
MDPI
Repository Status
Restricted
Socio-economic Objectives
Surface water quantification, allocation and impact of depletion