Brain functional connectivity abnormalities in attention-deficit hyperactivity disorder
Introduction: Recent evidence suggests that attention-deficit hyperactivity disorder (ADHD) is associated with brain functional connectivity (FC) abnormalities.
Methods: In this study, we use steady-state visually evoked potential event-related partial coherence as a measure of brain FC to examine functional connectivity differences between a typically developing (TD) group of 25 boys and an age/IQ-matched group of 42 drug naive boys newly diagnosed with ADHD (ADHD group). Functional connectivity was estimated while both groups performed a low-demand reference task and the A-X version of the continuous performance task (CPT A-X).
Results: While the TD and ADHD groups exhibited similar prefrontal FC increases prior to the appearance of the target in the reference task, these groups demonstrated significant FC differences in the interval preceding the appearance of the target in the CPT A-X task. Specifically, the ADHD group exhibited robust prefrontal and parietofrontal FC increases that were not apparent in the TD group.
Conclusion: The FC differences observed in the ADHD group are discussed in the context of inaddequate suppression of cortical networks that may interfere with task performance.
History
Publication title
Brain and BehaviorVolume
6Issue
12Article number
e00583Number
e00583Pagination
1-16ISSN
2162-3279Department/School
Wicking Dementia Research Education CentrePublisher
John Wiley & Sons Ltd.Place of publication
United KingdomRights statement
Copyright 2016 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/Repository Status
- Open