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Brain functional connectivity abnormalities in attention-deficit hyperactivity disorder

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posted on 2023-05-19, 00:02 authored by Silberstein, RB, Pipingas, A, Maree Farrow, Levy, F, Stough, CK, Camfield, DA

Introduction: Recent evidence suggests that attention-deficit hyperactivity disorder (ADHD) is associated with brain functional connectivity (FC) abnormalities.

Methods: In this study, we use steady-state visually evoked potential event-related partial coherence as a measure of brain FC to examine functional connectivity differences between a typically developing (TD) group of 25 boys and an age/IQ-matched group of 42 drug naive boys newly diagnosed with ADHD (ADHD group). Functional connectivity was estimated while both groups performed a low-demand reference task and the A-X version of the continuous performance task (CPT A-X).

Results: While the TD and ADHD groups exhibited similar prefrontal FC increases prior to the appearance of the target in the reference task, these groups demonstrated significant FC differences in the interval preceding the appearance of the target in the CPT A-X task. Specifically, the ADHD group exhibited robust prefrontal and parietofrontal FC increases that were not apparent in the TD group.

Conclusion: The FC differences observed in the ADHD group are discussed in the context of inaddequate suppression of cortical networks that may interfere with task performance.

History

Publication title

Brain and Behavior

Volume

6

Issue

12

Article number

e00583

Number

e00583

Pagination

1-16

ISSN

2162-3279

Department/School

Wicking Dementia Research Education Centre

Publisher

John Wiley & Sons Ltd.

Place of publication

United Kingdom

Rights statement

Copyright 2016 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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