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British anti-Lewisite and organomercury poisoning

journal contribution
posted on 2023-05-25, 22:42 authored by Canty, AJ, Kishimoto, R
2,3-Dimercaptopropanol, CH2(OH)CH(SH)CH2SH, also known as British anti-Lewisite, is generally used in the treatment of mercury poisoning to help remove mercury from the body. An understanding of the chemistry involved in the interaction of British anti-Lewisite with mercury compounds, and of the properties of any complexes formed, is necessary to understand the biological processes that occur on administration of the antidote, and its efficacy. We report here the characterisation of complexes formed with mercuric ion and with phenylmercury, the reactivity of the phenylmercury complex to form diphenylmercury, and the implications of these observations for the behaviour of British anti-Lewisite as an antidote for mercury poisoning.

History

Publication title

Nature

Volume

253

Article number

5487

Number

5487

Pagination

123-125

ISSN

0028-0836

Publication status

  • Published

Repository Status

  • Restricted

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