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CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse
journal contributionposted on 2023-05-17, 17:23 authored by Wiede, F, Fromm, PD, Comerford, I, Kara, E, Bannan, J, Schuh, W, Ranasinghe, C, Tarlinton, D, Winkler, T, McColl, SR, Heinrich KornerHeinrich Korner
The CC-chemokine receptor 6 (CCR6) is expressed constitutively at an intermediate level on naïve B cells and is upregulated after activation on pregerminal center (GC) B cells. We hypothesized that it could be involved in the events leading to GC reaction and high-affinity antibody production, and therefore investigated the potential role of CCR6 in B-cell differentiation in vivo. After antigenic challenge of CCR6−/− mice with the T-cell-dependent antigen nitrophenyl-keyhole limpet hemocyanin (NP-KLH), GC B-cell development was found to be accelerated and the number of GC had increased significantly compared with control mice, but the antibodies produced by CCR6−/− B cells were on average of lower affinity. We conclude from these data that the CCR6/CCL20 axis has an important role in regulating the kinetics and efficiency of the GC reaction.
Publication titleImmunology and Cell Biology
Department/SchoolMenzies Institute for Medical Research
PublisherNature Publishing Group
Place of publication54 University St, P O Box 378, Carlton, Australia, Victoria, 3053
Rights statementCopyright 2013 Australasian Society for Immunology Inc.