CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination
journal contribution
posted on 2023-05-17, 08:36 authored by Zawadzka, M, Rivers, LE, Fancy, SPJ, Zhao, C, Tripathi, R, Jamen, F, Kaylene YoungKaylene Young, Goncharevich, A, Pohl, H, Rizzi, M, Rowitch, DH, Kessaris, N, Suter, U, Richardson, WD, Franklin, RJMAfter central nervous system (CNS) demyelination - such as occurs during multiple sclerosis - there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, the great majority of reactive astrocytes in the vicinity of the lesions are derived from preexisting FGFR3-expressing cells, likely to be astrocytes. These data resolve a long-running debate about the origins of the main players in CNS remyelination and reveal a surprising capacity of CNS precursors to generate Schwann cells, which normally develop from the embryonic neural crest and are restricted to the peripheral nervous system. © 2010 Elsevier Inc.
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Publication title
Cell Stem CellVolume
6Issue
6Pagination
578-590ISSN
1934-5909Department/School
Menzies Institute for Medical ResearchPublisher
Cell PressPlace of publication
United StatesRepository Status
- Restricted
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