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Calcium influx pathways in breast cancer: opportunities for pharmacological intervention

journal contribution
posted on 2023-05-19, 16:16 authored by Iman AzimiIman Azimi, Roberts-Thomson, SJ, Monteith, GR
Ca(2+) influx through Ca(2+) permeable ion channels is a key trigger and regulator of a diverse set of cellular events, such as neurotransmitter release and muscle contraction. Ca(2+) influx is also a regulator of processes relevant to cancer, including cellular proliferation and migration. This review focuses on calcium influx in breast cancer cells as well as the potential for pharmacological modulators of specific Ca(2+) influx channels to represent future agents for breast cancer therapy. Altered expression of specific calcium permeable ion channels is present in some breast cancers. In some cases, such changes can be related to breast cancer subtype and even prognosis. In vitro and in vivo models have now helped identify specific Ca(2+) channels that play important roles in the proliferation and invasiveness of breast cancer cells. However, some aspects of our understanding of Ca(2+) influx in breast cancer still require further study. These include identifying the mechanisms responsible for altered expression and the most effective therapeutic strategy to target breast cancer cells through specific Ca(2+) channels. The role of Ca(2+) influx in processes beyond breast cancer cell proliferation and migration should become the focus of studies in the next decade.

History

Publication title

British Journal of Pharmacology

Volume

171

Issue

4

Pagination

945-60

ISSN

0007-1188

Department/School

School of Pharmacy and Pharmacology

Publisher

Nature Publishing Group

Place of publication

Macmillan Building, 4 Crinan St, London, England, N1 9Xw

Rights statement

Copyright 2013 The British Pharmacological Society

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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